A study comparing recovery features of patients undergoing general anaesthesia with rocuronium as muscle relaxant and recieving sugammadex or neostigmine and glycopyrollate for reversal.

A study comparing recovery characteristics of patients recieving either Sugammadex or Neostigmine and Glycopyrollate, for reversal of rocuronium induced Neuromuscular block - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/065600

Enrollment

109

Registered

2024-04-12

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K402- Bilateral inguinal hernia, withoutobstruction or gangrene Health Condition 2: K800- Calculus of gallbladder with acutecholecystitis Health Condition 3: N920- Excessive and frequent menstruation with regular cycle

Interventions

Intervention1: Sugammadex: 2mg/kg given at TOF count of 2. Given only once at the time of extubation. Control Intervention1: Neostigmine and Glycopyrollate: Neostigmine 2.5 mg and glycopyrollate 0.4 m

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists grades 1, 2, and 3 patients aged 18–60 years, coming for elective laparoscopic surgeries (lasting one to three hours) will be recruited for the study.

Exclusion criteria

Exclusion criteria: 1. Patients with cardiorespiratory abnormalities (New York Heart Association heart failure grades 3 and 4. 2. Known allergy to Rocuronium. 3. Renal insufficiency (eGFR 4. Liver dysfunction (liver enzymes—serum glutamic oxaloacetic transaminase/ serum glutamic pyruvic transaminase values elevated by more than 50% of normal). • Underlying neuromuscular disease or the use of drugs known to interfere with neuromuscular transmission. • Intraoperative hypothermia (core temperature less than 35°C). • Known Emphysema. • Unwillingless to perform PFT.

Design outcomes

Primary

Measure	Time frame
Time taken for complete reversal of neuromuscular blockTimepoint: Reversal given at TOF count of 2 and time taken to reach TOF ratio 0.9. It is checked at the end of each case at the time of extubation.	—

Secondary

Measure	Time frame
To compare post operative respiratory function in terms of PFTTimepoint: PFT to be done in post anaesthesia care unit 20 minute after extubation	—

Countries

India

Contacts

Public ContactSameer Akthar B

Manipal Hospital

drhsmurthy@gmail.com8111053116

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026