Effect of cold irrigation on post operative pain after single visit root canal treatment

Evaluation of the effect of intracanal cryotreated sodium hypochlorite on post obturation pain in single visit root canal treatment - A comparative clinical trial - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/065587

Enrollment

Registered

2024-04-12

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K044- Acute apical periodontitis of pulpal origin

Interventions

Intervention1: Cryotreated 5.25 % sodium hypochlorite irrigation and final rinse with room temperature normal saline: After preparing root canals upto to 30/0.4 % size, 20ml of cryotreated 5.25 % sodi

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients in the age group of 20 –40 years who require endodontic therapy in mandibular premolars and have signed the informed consent. 2.Mandibular premolars diagnosed with vital symptomatic irreversible pulpitis with normal periapical tissues / symptomatic apical periodontitis. 3.Healthy patients without systemic disease.

Exclusion criteria

Exclusion criteria: 1.Medically compromised patients. 2.Pregnant patients. 3.Teeth with incomplete apex formation. 4.Teeth with calcified canals. 5.Patients with swelling, sinus formation. 6.Periodontally weakened tooth. 7.Periapical abscess and periapical radiolucency. 8.Patients on antibiotic therapy. 9.Teeth with history of trauma (i.e, TFO, Fractured cusps, etc). 10.Patients on analgesics.

Design outcomes

Primary

Measure	Time frame
Reduction of post operative pain using cryotreated irrigant after single visit root canal treatmentTimepoint: 6 hours after root canal treatment 12 hours after root canal treatment 24 hours after root canal treatment 48 hours after root canal treatment 4 days after root canal treatment 7 days after root canal treatment	—

Secondary

Measure	Time frame
Improved efficacy due to increased duration of intracanal sodium hypochlorite Timepoint: one week after root canal treatment	—

Countries

India

Contacts

Public ContactJagvinder singh mann

Government Dental College and Hospital, Patiala, Punjab

naveenprasath.96@gmail.com9842543278

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026