To Evaluate if intravesical epinephrine irrigation improves the postoperative outcomes in patients undergoing resection of Bladder Tumor as compared to normal saline irrigation

A Randomized Controlled Trial on Evaluating the safety and efficacy of intravesical epinephrine irrigation on postoperative outcomes in patients undergoing Transurethral resection of Bladder Tumor. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/065584

Enrollment

134

Registered

2024-04-12

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N328- Other specified disorders of bladder

Interventions

Intervention1: Intravesical epinephrine: In the post operative period, the test group will receive continuous intravesical bladder irrigation with 1:100,000 diluted epinephrine (10 ml 1:1000 epinephr

Eligibility

Inclusion criteria

Inclusion criteria: Patients with bladder tumor undergoing TURBT Patients undergoing en-bloc resection of bladder tumour Patients undergoing en-bloc resection of bladder tumour using laser (HOLERBT)

Exclusion criteria

Exclusion criteria: ASA Grade 3 or more. Patients with incomplete tumour clearance Patients undergoing TUR biopsy for large bladder mass Patients undergoing restaging TURBT Patients with intraoperative deep bladder resection that requires prolonged catheterization Patients with congenital or acquired Hyper/ hypocoagulation disorders. Patients with hematological malignancies. Patients with decompensated chronic liver disease or renal impairment or other bleeding diathesis. Patients with a history of thromboembolic disease. Patients with history of arrhythmias Patients with uncontrolled hypertension ? Patients with a history of acute coronary syndrome within the past 12 months

Design outcomes

Primary

Measure	Time frame
To compare the mean indwelling catheter time in patients undergoing TURBT in those receiving intravesical normal saline vs continuous epinephrine solution irrigationTimepoint: at discharge	—

Secondary

Measure	Time frame
1. To compare the postoperative hematuria in patients undergoing TURBT in those receiving intravesical normal saline vs continuous epinephrine solution irrigation 2. To compare the length of hospitalization in patients undergoing TURBT in those receiving intravesical normal saline vs continuous epinephrine solution irrigation 3. To compare the secondary hematuria in patients undergoing TURBT in those receiving intravesical normal saline vs continuous epinephrine solution irrigationTimepoint: 6 hrs , 12 hrs , 1 month	—

Measure

Time frame

1. To compare the postoperative hematuria in patients undergoing TURBT in those receiving intravesical normal saline vs continuous epinephrine solution irrigation 2. To compare the length of hospitalization in patients undergoing TURBT in those receiving intravesical normal saline vs continuous epinephrine solution irrigation 3. To compare the secondary hematuria in patients undergoing TURBT in those receiving intravesical normal saline vs continuous epinephrine solution irrigationTimepoint: 6 hrs , 12 hrs , 1 month

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Countries

India

Contacts

Public ContactSaharsh Ambade

All India Institute Of Medical Science, Bhubaneswar

urol_swarnendu@gmail.com8447562972

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026