Health Condition 1: N04- Nephrotic syndrome
Conditions
Interventions
Intervention1: SSA with Prednisolone: 1. Syp Cyclosporine (100mg/ml) @ 5 mg/kg/day (max dose 250 mg) in divided doses
or
2. Tab Tacrolimus 0.2 mg/kg/day (maximum 10 mg) in 2 divided doses
or
3. Tab My
Sponsors
SCB Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Frequently relapsing nephrotic syndrome patients aged 1-14 years. 2. Steroid-dependent nephrotic syndrome patients aged 1-14 years requiring SSA. 3. Any nephrotic patient on SSA. 4. At least 6 months of follow-up from the time of enrollment in the study.
Exclusion criteria
Exclusion criteria: 1. Children who have secondary cause for FRNS/SDNS. 2. SRNS, infantile and congenital NS. 3. Children who have received Rituximab six months prior to enrollment into the study. 4. Children already on prednisolone therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the efficacy of early initiation of steroid-sparing agents with daily dose of prednisolone compared to only prednisolone therapy in achieving remission among patients aged 1-14 years diagnosed with FRNS/SDNS.Timepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare any increase in the risk of serious infection associated with the two different approaches in these children.Timepoint: 6 months;To observe the number of relapses in both intervention arms.Timepoint: 6 months | — |
Countries
India
Contacts
Public ContactDr Aishwarya Chandra
SCB Medical College and Hospital
Outcome results
None listed