Drugs to decrease BP response for skin incision in Brain surgery

Dexmedetomidine vs fentanyl as an adjuvant to ropivacaine for scalp block in attenuating hemodynamic response to skull pin insertion and scalp incision in supratentorial craniotomies - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/065516

Enrollment

100

Registered

2024-04-10

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine group (Group D): dexmedetomidine (1µgm/kg) will be added to 20 ml of 0.5% ropivacaine scalp block on each side Intervention2: Fentanyl group (Group F): Fentanyl (1µgm

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA 1-2 2. Elective supratentorial craniotomies 3. GCS: 15

Exclusion criteria

Exclusion criteria: 1. ASA: 3-4 2.Preop GCS 3. Delayed recovery or postop mechanical ventilation 4. GCS 5. Local anaesthetic allergy 6. Bradycardia( 7. Emergency indication

Design outcomes

Primary

Measure	Time frame
Mean arterial pressureTimepoint: 10 minutes after skull pin insertion	—

Secondary

Measure	Time frame
Heart rate, visual analogue scale, duration of analgesia, ramsay sedation score, potsop fentanyl requirement, opioid sede effectsTimepoint: skull pin insertion, scalp incision, postop Postop VAS Scores at 15 ,30 min 1hr, 2hr 4h,r 8 hr opiod requirement & side effects.	—

Countries

India

Contacts

Public ContactMohammad Farooq

Nizams Institute of Medical Sciences Hyyderabad: Pincode: 500082

farooqyadwad@gmail.com7207501876

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026