Comparison of effectiveness of levobupivacaine0.5%vs ropivacaine 0.75% mixed with dexmedetomidine after lumbar epidural anaesthesia in long bone surgeries

Comparison of efficacy, BIS value and haemodynamic spectrum of levobupivacaine 0.5% versus ropivacaine 0.75% with dexmedetomidine as an adjuvant following lumbar epidural anaesthesia in long bone surgeries - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/065483

Enrollment

120

Registered

2024-04-09

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Lumbar Epidural Anaesthesia: Lumbar epidural block is given at L3-L4 intervertebral space via 18G/16G tuohys epidural needle using LOR technique.epidural catheter is inserted then test

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18 to 65 year ASA I-II BMI (18.5-35) Either gender Patients undergoing elective long bone surgeries

Exclusion criteria

Exclusion criteria: Patient refusal Bilateral lower limb surgeries Focal neurological deficits Inability to understand VAS Coagulation disorders Severe spinal deformities Infection at the site of block Pre existing peripheral neuropathy Uncontrolled Diabetes mellitus Known hypersensitivity to Local anaesthetics

Design outcomes

Primary

Measure	Time frame
1.Characteristic of motor & sensory block (min) 2.BIS index score Timepoint: SENSORY BLOCK 1: Onset time to T10 - time taken for sensory blockade to pain at T10 level since the time of Drug injection by Pin Prick Method 2: Maximal sensory level 3: Time to maximal Sensory level 4: Time to two dermatome regression 5: Time to regression to T10 6: Time to regression to L1 MOTOR BLOCK 1 :Time to complete block as per Modified Bromage Scale 2 :Time to complete recovery BIS Score Index :0 to 180 min	—

Measure

Time frame

1.Characteristic of motor & sensory block (min) 2.BIS index score Timepoint: SENSORY BLOCK 1: Onset time to T10 - time taken for sensory blockade to pain at T10 level since the time of Drug injection by Pin Prick Method 2: Maximal sensory level 3: Time to maximal Sensory level 4: Time to two dermatome regression 5: Time to regression to T10 6: Time to regression to L1 MOTOR BLOCK 1 :Time to complete block as per Modified Bromage Scale 2 :Time to complete recovery BIS Score Index :0 to 180 min

—

Secondary

Measure	Time frame
1.Incidence of adverse effects 2.Requirements of 1st Rescue analgesic 3.Duration of analgesia 4.Patient satisfactionTimepoint: Till 6 hours post surgery	—

Countries

India

Contacts

Public ContactDr Poonam Lata Singh Thakur

Bharat Ratna Late Shri Atal Bihari Vajpayee Memorial Medical College Rajnandgaon

drsmriti19@gmail.com7000562486

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026