TO COMPARE NOREPINEPHRINE VERSUS MEPHENTERMINE ON SPINAL ANAESTHESIA INDUCED HYPOTENSION IN INFRAUMBILICAL SURGERIES

COMPARISION OF BOLUS NOREPINEPHRINE VERSUS MEPHENTERMINE ON SPINAL ANAESTHESIA INDUCED HYPOTENSION IN INFRAUMBILICAL SURGERIES:A RANDOMISED CLINICAL STUDY - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/065451

Enrollment

Registered

2024-04-09

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K409- Unilateral inguinal hernia, without obstruction or gangrene

Interventions

Intervention1: Injection norepinephrine: Injection norepinephrine 10mcg given IV for prevention of spinal anaesthesia induced hypotension Control Intervention1: Injection Mephentermine: Injection Meph

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I and II posted for infraumbilical surgeries

Exclusion criteria

Exclusion criteria: a. Patient not willing to give informed consent b. ASA grade III and IV c. Weight less than 50kgs and more than 90kgs d. Height less than 150cm and more than 180cm e. Parturient undergoing caesarian section f. Patients with significant coagulopathies and other contraindications for spinal anesthesia

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of bolus Norepinephrine and mephentermine on Spinal Anesthesia induced hypotension in patients undergoing infraumbilical surgeriesTimepoint: Baseline,3 minutes,6 minutes,9 minutes,12 minutes,15 minutes,20 minutes till the procedure ends	—

Secondary

Measure	Time frame
1.Incidence of hypotension 2.Number of bolus doses of study drug required between the groups 3.Incidence of tachycardiaTimepoint: Every 3 minutes for first 15 minutes, then for every 5 minutes for the rest of the time	—

Countries

India

Contacts

Public ContactDr Madhu K P

Bangalore Medical College and research institute

drmadhukp@gmail.com9448727374

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026