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Comparison of single versus double dose of recombinant human chorionic gonadotropin on final oocyte maturation in IVF cycles

To compare the effect of single versus double dose of recombinant human chorionic gonadotropin on final oocyte maturation in long agonist in vitro fertilisation cycles- A Prospective Randomized Controlled Study - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/04/065398
Enrollment
374
Registered
2024-04-08
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N979- Female infertility, unspecified

Interventions

Intervention1: Double dose of recombinant human chorionic gonadotropin: 500mcg (250 x 2) of recombinant human chorionic gonadotropin injection stat dose Control Intervention1: Single dose of recombina

Sponsors

Amrita Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All women between the age group of 21–40 years with normal or poor ovarian reserve undergoing IVF ET by Long Agonist Protocol.

Exclusion criteria

Exclusion criteria: History of OHSS High basal ovarian reserve (AMH more than 8ng/ml or AFC more than 24) Hyper response (more than 18 follicles of diameter 11mm or more)

Design outcomes

Primary

MeasureTime frame
To compare the effect of single versus double dose of recombinant human chorionic gonadotropin on total number of M-II oocytes retrieved per follicle.Timepoint: 38 hours—

Secondary

MeasureTime frame
Biochemical pregnancy rateTimepoint: 2-3 weeks;Clinical pregnancy rateTimepoint: 5-6 weeks;Incidence of OHSSTimepoint: 7-10 days;Number of good quality embryos generated.Timepoint: 4-5 days—

Countries

India

Contacts

Public ContactDr Aashim Garg

Amrita Institute of Medical Sciences

fessylouis@gmail.com9846055224

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026