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To Determine the Predictors of Reversibility for Acute-on-Chronic Liver Failure (liver disease) at 6-months.

To Determine the Predictors of Reversibility for Acute-on-Chronic Liver Failure at 6-months-A Prospective Study - NIL

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/04/065297
Enrollment
480
Registered
2024-04-05
Start date
Unknown
Completion date
Unknown
Last updated
2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K758- Other specified inflammatory liverdiseases

Interventions

Intervention1: None: None

Sponsors

Institute of Liver and Biliary Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age - 18-75 years 2. Patients with ACLF(as per APASL guidelines) admitted in department of Hepatology. 3. Acute Insult-Alcohol,HBV,Auto-immune hepatitis,Viral hepatitis,Drug Induced Liver Injury

Exclusion criteria

Exclusion criteria: 1. Acute decompensation 2. Complete portal vein thrombosis 3. Hepatocellular carcinoma 4. Tumoral portal vein thrombosis 5. Chronic kidney disease 6. Pregnancy 7. Failure to give consent

Design outcomes

Primary

MeasureTime frame
To determine the predictors based on baseline clinical and biochemical parameters and available non-invasive tests for prediction of reversibility at 6-months,in ACLF patients.Timepoint: 6-months—

Secondary

MeasureTime frame
Association of baseline AARC score with 90-day and 6-months reversibilityTimepoint: 3 and 6 months;Association of degree of fibrosis with 90-day and 6-months reversibility.Timepoint: 3 and 6 months;Association of delta Liver Stiffness Measurement(at baseline and 28-day)with 90-day and 6-months reversibilityTimepoint: 28 days,3 and 6 months;Association of delta Spleen Stiffness Measurement(at baseline and 28-day)with 90-day and 6-months reversibilityTimepoint: 28 days,3 and 6 months;Proportion of patients achieving 90-day(early)reversibility.Timepoint: 3 months;Proportion of patients achieving reversibility.Timepoint: 6 months;Proportion of patients maintaining reversibility till 1-year.Timepoint: 1 year;Proportion of patients with cirrhotic ACLF achieving re compensation at 1-year.Survival at 1-yr. Liver transplant at 1-year.Timepoint: 1 year—

Countries

India

Contacts

Public ContactDr V Rajan

Institute of Liver and Biliary Sciences

rajanvf40@gmail.com01146300000

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026