Comparison of the Haemodynamic effects of nasal intermittent positive pressure ventilation and nasal continuous positive pressure ventilation in preterm neonates with respiratory distress syndrome - a randomised controlled trial

Haemodynamic effects of nasal intermittent positive pressure ventilation NIPPV vs nasal continuous positive pressure ventilation NCPAP in preterm neonates with respiratory distress syndrome a randomised controlled trial - -

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/065278

Enrollment

Registered

2024-04-05

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: P220- Respiratory distress syndrome of newborn

Interventions

Intervention1: NIPPV: one arm of the study will include preterm neonates with respiratory distress who have been extubated after surfactant administration to receive NIPPV. Functional ECHO will be do

Eligibility

Inclusion criteria

Inclusion criteria: Preterm neonates admitted to NICU during the study period of gestational age 26 to 36+6/7 weeks, who have received invasive mechanical ventilation, surfactant atherapy and then extubated to non-invasive respiratory support (NIPPV or NCPAP).

Exclusion criteria

Exclusion criteria: 1)major congenital malformation 2)extubation failure within 24hrs requiring reintubation 3)neonatal sepsis 4)inotropic support in last 24 hrs 5)moderate to severe HIE 6)haemodynamically significant PDA 7)moderate to severe pulmonary hypertension

Design outcomes

Primary

Measure	Time frame
To compare the right ventricular systolic and diastolic functions in preterm infants on NIPPV versus NCPAP, 4-6 hours and 18-24 hours after extubation using Fn ECHO. To compare the left ventricular systolic and diastolic functions in preterm infants on NIPPV versus NCPAP, 4-6 hours and 18-24 hours after extubation using Fn ECHO. Timepoint: 4-6 hours and 18-24 hours	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Pradeep Suryawanshi

bharati vidyapeeth deemed university pune maharashtra

drpradeepsuryawanshi@gmail.com9923540500

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 13, 2026