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Superiority of High Flow Nasal Cannula over Non Invasive Ventilation for treatment CO2 retention

Comparison of efficacy of high flow oxygen through nasal cannula with standard treatment in patients presenting with Type 2 respiratory failure - Comparison of efficacy of high flow oxygen through nasal cannula with standard treatment in patients presenting with Type 2 respiratory failure - Randomised clinical trial Comparison of efficacy of high flow oxygen through nasal cannula with standard treatment in patients presenting with Type 2 respiratory failure - Randomised clinical trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/04/065272
Enrollment
86
Registered
2024-04-05
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: J969- Respiratory failure, unspecified

Interventions

Intervention1: High flow oxygen through nasal cannula: Hospital based,prospective,unblinded, randomised clinical trial.This study will include all patients with Type 2 respiratory failure presenting t

Sponsors

AIIMS Patna
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with Type 2 respiratory failure with arterial PCO2 of greater than and equal to 45mm hg. Able to take own respiratory efforts

Exclusion criteria

Exclusion criteria: Denying consent Anatomical lesions of upper airway and its obstruction Central apnoea. Blocked nasal passages choanal atresia. Trauma surgery to nasopharynx. Pneumothorax Requiring invasive ventilation. Respiratory arrest Unable to protect airways Craniofacial trauma Facial oesophageal gastric surgery Pregnant Altered sensorium

Design outcomes

Primary

MeasureTime frame
To assess the fall in arterial partial pressure of CO2 by high flow oxygen through nasal cannula in comparison with non invasive ventilation in patients presenting with Type 2 respiratory failure in emergency department Timepoint: ABG parameters hourly for three hours—

Secondary

MeasureTime frame
treatment failures will be addressedTimepoint: Three Hours—

Countries

India

Contacts

Public ContactDr.Divendu Bhushan

AIIMS,Patna

drdivendubhushan@aiimspatna.org9661216010

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026