Health Condition 1: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx
Conditions
Interventions
Intervention1: Drug dexamethasone and methylphenidate: To compare effectivity of methylphenidate and dexamethasone
There will be two following groups
1. Dexamethasone group eligible subjects taking 8m
Sponsors
Nil
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 18 and above 2. Registered in palliative care centre 3. Suffering from histologically diagnosed advanced cancer 4. Patient with cancer related fatigue score greater than or equal to 4 to 10 on Edmonton symptoms assessment scale 5. Patient giving written informed consent
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating female 2. Known history of hypersensitive to study drugs 3. History of AIDS 4. History of surgery in the last 2 weeks 5. Abnormal T3,T4,TSH 6. Anemia (Hb less than9) 7. Known case of Diabetes mellitus, Hypertension 8. Severe renal impairment, 9. Severe liver impairment, 10. Significant disorder of bone marrow 11. Cardiac conduction defect. 12. Patient taking Antipsychotic, sedative- psychotropic drug. Atropine and its substitute 13. Non co-operative patient 14. Patients who were not able to answer the questionnaires
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.FatigueTimepoint: Change in fatigue score will be assessed i.e 1 st week and 2 nd week | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Effect on appetite 2.Effect on psychological symptoms 3. Adverse eventsTimepoint: 1.change in appetite will be assessed i.e. baseline, 1st week,2 nd week 2.change in effect of psychological symptoms will be assessed i.e. baseline, 1st week and 2nd week 3. Adverse events will be assessed i.e baseline,1 st week,2 nd week | — |
Countries
India
Contacts
Public ContactDr.Ashwin Mathur
Sawai Man Singh medical college and attached hospital
Outcome results
None listed