Health Condition 1: Q211- Atrial septal defect
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
AIIMS Delhi Research Section
Eligibility
Inclusion criteria
Inclusion criteria: 1. Isolated OS-ASD with sufficient rims(more than 5mm 2. Net left to right shunt more than 1.5:1 3. RA and RV volume overload 4. Pulmonary vascular resistance (PVR) is less than one-third of Systemic vascular resistance (SVR) 5. Pulmonary artery systolic pressure (PASP) less than 50 percent of Systolic blood pressure (SBP) 6. No cyanosis at rest or during exercise 7. Age more than 18 years and less than 70 years. 8. Willing to give informed consent.
Exclusion criteria
Exclusion criteria: 1. ASD not amenable to device closure i. Ostium secundum ASD with insufficient rims (less than 5mm) ii. ASDs other than Ostium secundum ASD iii. ASD is associated with other congenital anomalies. 2. Eisenmenger syndrome 3. Patient is undergoing surgical patch closure of ASD. 4. Contraindications for MRI a. MRI incompatible implants b. Claustrophobia c. Renal insufficiency d. Pregnant women 5. Not willing to give consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in interstitial fibrosis level of right atrium and ventricle after ASD device closure as assessed by cardiac magnetic resonance imaging (MRI)Timepoint: One year follow up | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in echocardiographic parameters of cardiac remodeling including â?? volume status, function, and strain pattern of right atrium and right ventricle after ASD device closureTimepoint: One year follow up;Relationship between different pre device closure demographic, cardiac variables (like- age, gender, ASD size, cardiac volumes, fibrosis levels, Cath study parameters) and post device closure cardiac reverse remodeling including fibrosis levelTimepoint: One year follow up;Clinical significance of post atrial device closure cardiac reverse remodeling including change in fibrosis level in terms of cardiac arrhythmiaTimepoint: One year follow up | — |
Countries
India
Contacts
Public ContactDr Nirmal Ghati
Department of Cardiology, All India Institute of Medical Sciences, New Delhi
Outcome results
None listed