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Comparison of two drugs for pain relief after operation in patients of brain tumor excision using local anaesthesia

Effects of Dexmedetomidine and Morphine as adjuvants to Ropivacaine in comparison with plain ropivacaine 0.5%for pre-operative bilateral scalp block for post-operative pain relief in patients undergoing elective supratentorial craniotomy. A Prospective Randomized Controlled Double Blind Study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/04/065127
Enrollment
93
Registered
2024-04-03
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C700- Malignant neoplasm of cerebral meninges Health Condition 2: C710- Malignant neoplasm of cerebrum, except lobes and ventricles Health Condition 3: C711- Malignant neoplasm of frontal lobe Health Condition 4: C711- Malignant neoplasm of frontal lobe Health Condition 5: C711- Malignant neoplasm of frontal lobe Health Condition 6: C714- Malignant neoplasm of occipital lobe Health Condition 7: C713- Malignant neoplasm of parietal lobe Health Condition 8: C712- Malignant neop

Interventions

Intervention1: Comparison of 2 adjuvants Dexmedetomidine: Group D will receive 0.5% ropivacaine (22ml) and dexmedetomidine 2ml (50mcg diluted in volume of 2ml) for scalp block after induction of anest

Sponsors

Paras Hospitals Gurgaon
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1,2 Patients undergoing elective supratentorial craniotomy GCS > 13-15

Exclusion criteria

Exclusion criteria: Known allergy to study drugs. Refusal of consent. Anticipated duration of surgery >6 hours. Preoperative HR Past history of craniotomy. Pregnancy and lactation. Patients unable to understand pain scores.

Design outcomes

Primary

MeasureTime frame
To compare the post-operative analgesic requirement for first 24 hours after surgery.Timepoint: At the end of surgery and final evaluation after 1 year—

Secondary

MeasureTime frame
1. To compare intraoperative analgesic requirements. 2. To compare intraoperative hemodynamic parameters and their correlation with qnox values. 3. To compare side-effects profile in all three groups. 4. To compare pain scores using VAS values for first 24 hours in all three groups. Timepoint: During the surgery, at the end of the procedure and final evaluation after 1 year—

Countries

India

Contacts

Public ContactDr Mukesh Mohan Gupta

Paras Hospitals

docmmg@gmail.com9871174766

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026