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To evaluate the efficacy of pretreatment of vein with plain intravenous lignocaine before propofol with that of premixed solution of lignocaine and propofol to decrease pain on injection during propofol induction of anaesthesia:

Comparison of the efficacy of pretreatment of vein with plain intravenous lignocaine before propofol with that of premixed solution of lignocaine and propofol to decrease pain on injection during propofol induction of anaesthesia: a prospective, randomized double blind study. - NA

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/04/065103
Enrollment
120
Registered
2024-04-02
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I999- Unspecified disorder of circulatory system

Interventions

Intervention1: Group A will receive study drug 1 with 10 ml of NS before tourniquet application and then study drug 2 with 10 ml of Propofol mixed with 1ml of intravenous Lignocaine will be administer

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients who need propofol as induction anaesthetic agent in providing general anaesthesia for the surgery Patients between age 18-65 Years of either sex. Patients belongs to American Society of Anaesthesiologists (ASA) physical status classification system grades of I, II & III [45](Annexure – 3) will be included into the study.

Exclusion criteria

Exclusion criteria: Unwilling participants. Patients belongs to ASA grade more than three. Patients with hemodynamic instability precluding the use of propofol. Patients with a history of Hypersensitivity to study drugs. Patients who are Allergy to eggs and soya. Patients with poor venous access . Pregnant and lactating women.

Design outcomes

Primary

MeasureTime frame
To evaluate the intensity of pain during propofol induction.Timepoint: 0 minute, 1 minute , 2minute, 3minute—

Secondary

MeasureTime frame
To compare the haemodynamic changes associated with the interventions upon propofol administration (Heart rate - HR, Systolic Blood Pressure - SBP, Diastolic Blood Pressure - DBP and Mean Arterial Pressure - MAP). Adverse events: Allergic reactions (chills & rigors, urticarial rashes, itching, swelling at the site of injection), arrhythmias during the study period and incidence of severe thrombophlebitis (tenderness and erythema) within 24 hours will also be observed. Timepoint: 0 minute, 1 minute , 2minute, 3minute and 24hrs—

Countries

India

Contacts

Public ContactDr.Shaik Khaja Rasool

Sri venkateswara institute o medical sciences

subhadrapeyyety@gmail.com9490573073

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026