Comparison of 2 medicines- Amisulpride and Ondansetron to find out which is better for preventing Nausea and vomiting following Laparoscopic Gynaecological surgery.

Comparison of Amisulpride and Ondansetron for the prevention of Postoperative Nausea and Vomiting in patients undergoing laparoscopic gynaecological surgeries - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/065036

Enrollment

200

Registered

2024-04-01

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Amisulpride: Preoperatively just before induction of Anaesthesia,group A patients will be given a single dose of Amisulpride 5mg slow i.v. over 30 seconds. Intervention2: Ondansetron:

Eligibility

Inclusion criteria

Inclusion criteria: Females undergoing Laparoscopic Gynaecological surgery.

Exclusion criteria

Exclusion criteria: Patients having history of motion sickness or past history of PONV. Smokers. History of allergy to the drug to be given. Patients with liver disease. Patients receiving chemotherapy or radiotherapy within the past four weeks.

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative nausea and vomiting in the first 24 hours following surgery measured using postoperative Nausea score, Postoperative vomiting score and PONV scoreTimepoint: From end of surgery to 24 hrs after end of surgery	—

Secondary

Measure	Time frame
1) Requirement of rescue anti-emetic in both groups. 2) Incidence of adverse effects like headache, dizziness, dizziness etcTimepoint: From administration of drug to 24 hrs after end of surgery	—

Countries

India

Contacts

Public ContactDr Rupesh Yadav

ABVIMS and Dr.RML Hospital

drrupesh.yadav98@gmail.com9460720444

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026