Effects of co2 on arterial oxygenation during one lung ventilation.

A Randomized comparative study to compare the effect of normocarbia vs permissive hypercarbia on arterial oxygenation during one lung ventilation in lung surgeries at SMS medical college , jaipur - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

CTRI

Registry ID

CTRI/2024/04/065019

Enrollment

Registered

2024-04-01

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J00-J99- Diseases of the respiratory system

Interventions

Intervention1: Hypercarbia: During one lung ventilation we will maintain permissive hypercarbia upto 50 by changing respiratory rate for 30minutes Control Intervention1: Normocarbia: We will maintain

Eligibility

Inclusion criteria

Inclusion criteria: Age above 18 years ASA grade 1 to 3 Patients undergoing elective lung surgeries (thoracotomy, pneumonectomy, lobectomy, bilobectomy, segmentectomy etc.) Patients who will give informed written consent

Exclusion criteria

Exclusion criteria: 1.Patient should not be a part of other study. 2.Non co-operative patient. 3 .Patient who presented with cardiac arrhythmias 4. History of heart failure, vascular disease, chronic obstructive pulmonary disease, restrictive pulmonary disease or increased increased intracerebral pressure 5. Evidence of any liver or kidney disease 6. Patients with haemostatic disorders 7. Previously existing chronic respiratory disease of non-operated lung

Design outcomes

Primary

Measure	Time frame
Mean PaO2 in both study group. Mean change in haemodynamic variables- HR,SBP,DBP,MAP Mean change in respiratory variables - Pmean, Pplateau, dynamic compliance etc Timepoint: Baseline , after 30 minutes	—

Secondary

Measure	Time frame
Mean change in heamodynamic variables and respiratory variablesTimepoint: 30 minutes	—

Countries

India

Contacts

Public ContactDr Anjana Kumari meena

Sms medical college , jIpur

dr.induverma@gmail.com94139622967

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026