Health Condition 1: - Health Condition 2: G939- Disorder of brain, unspecified
Conditions
Interventions
Intervention1: Fluid challenge: Fluid challenge: Ringers lactate solution will be infused intravenously over a 10-min period with a total infusion volume of 6 mL per kg that served to observe fluid re
Sponsors
TNMC and BYL Nair Ch. Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patients posted for routine major surgeries in plastic and neurosurgery OT under general anaesthesia and mechanical ventilation Arterial cannulation done as a part of routine protocol ASA 1 and 2
Exclusion criteria
Exclusion criteria: Pregnancy, Patients with cardiac and respiratory ailments Raised intracranial pressure Contraindication of fluid challenge (acute coronary syndrome, cardiac shock, and evidence of capacity overload)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Accuracy of PPV in predicting volume responsiveness can be increased by increasing TV. Optimal TV that enables best diagnostic value is 10 ml/kg. The diagnostic value of PPV is higher than that of IVC DI.Timepoint: TV adjustment will be carried out after about 10 min when the hemodynamics of the patient become stable. The TV will be adjusted to 8 mL/kg. The parameters will be recorded. The TV will be adjusted to 10 mL/kg after 2 min. The indices will be recorded after maintenance for 2 min. Then Fluid challenge will be given. The tidal volumes of 8 and 10 mL/kg will be adjusted immediately after the fluid challenge and maintained for 2 min, and then the above indices will be recorded again. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in VTI with fluid challengeTimepoint: TV adjustment will be carried out after about 10 min when the hemodynamics of the patient become stable. The TV will be adjusted to 8 mL/kg. The parameters will be recorded. The TV will be adjusted to 10 mL/kg after 2 min. The indices will be recorded after maintenance for 2 min. Then Fluid challenge will be given. The tidal volumes of 8 & 10 mL/kg will be adjusted immediately after the fluid challenge and maintained for 2 min, & then the above indices will be recorded again. | — |
Countries
India
Contacts
Public ContactYogesh Ganesh Chawat
TNMC BYL Nair Ch. Hospital
Outcome results
None listed