Effect of study drugs fentanyl, dexmedetomidine and lidocaine on extubation quality and the changes in the blood pressure, heart rate and oxygen saturation.

Effect on quality of extubation and hemodynamic response - comparison between fentanyl, dexmedetomidine and lidocaine, a prospective randomised study. - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/064980

Enrollment

Registered

2024-04-01

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine and lidocaine: Using fentanyl as a standard of care the drugs are compared for extubation response. After the MAC is zero, one group of patients will be given dexmedeto

Eligibility

Inclusion criteria

Inclusion criteria: ASA I and II Posted for elective laparoscopic cholecystectomy

Exclusion criteria

Exclusion criteria: BMI more than 30 kg/m2 Predicted airway difficulty Significant comorbidities Patients on heart rate control drugs History of recent upper respiratory tract infections Local anaesthetic allergy Coagulation abnormalities Not willing for consent

Design outcomes

Primary

Measure	Time frame
ASSESSMENT OF QUALITY OF EXTUBATION, AIRWAY RESPONSE AND HEMODYNAMIC RESPONSE IS THE PRIMARY OUTCOME OF THE STUDY.Timepoint: BASELINE VITALS A0 (just before the study drug administration) A1 (one minute after study drug administration) A5 (five minutes after study drug administration) E0 (before extubation) E1 (one minute after extubation) E5 (five minutes after extubation) E10 (ten minutes after extubation)	—

Measure

Time frame

ASSESSMENT OF QUALITY OF EXTUBATION, AIRWAY RESPONSE AND HEMODYNAMIC RESPONSE IS THE PRIMARY OUTCOME OF THE STUDY.Timepoint: BASELINE VITALS A0 (just before the study drug administration) A1 (one minute after study drug administration) A5 (five minutes after study drug administration) E0 (before extubation) E1 (one minute after extubation) E5 (five minutes after extubation) E10 (ten minutes after extubation)

—

Secondary

Measure	Time frame
To assess for adverse effects like sedation, respiratory depression, hypotension and BradycardiaTimepoint: 1 year	—

Countries

India

Contacts

Public ContactDr Moguram Soumya

Nizams institute of medical sciences

docarchana.pathy@gmail.com8885494278

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026