Association Between Concentration of Neutrophil Extracellular Traps and Outcome of Pulpotomy (a type of dental treatment to maintain the vitality of teeth) in Permanent Mature Teeth with symptoms of Irreversible Pulpal inflammation- A Prospective Cohort Study

Association between concentration of neutrophil extracellular traps and outcome of pulpotomy in permanent mature teeth with symptomatic irreversible pulpitis- A prospective cohort study - NIL

Status

Recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/064970

Enrollment

Registered

2024-04-01

Start date

Unknown

Completion date

Unknown

Last updated

2024-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Pulpotomy: In pulpotomy, the coronal inflamed dental pulp tissue will be removed using a bur and cotton pellet moistened with 2.5% sodium hypochlorite will be applied at the orifices fo

Eligibility

Inclusion criteria

Inclusion criteria: Healthy patient of either gender belonging to 15-45 years of age group Posterior teeth with extremely deep caries and established clinical diagnosis of symptomatic irreversible pulpitis without periapical rarefaction Positive response to cold and electric pulp tests Teeth with restorable carious lesions

Exclusion criteria

Exclusion criteria: Patients with immature teeth, periodontal diseases, and subgingival caries Presence of sinus tract or swelling or periapical pathology on an IOPA radiograph. Patients with systemic conditions which could compromise the healing like uncontrolled diabetes, bleeding disorders, immunosuppression etc. Patients with history of antibiotics intake in the last 14 days and analgesics in the last 7 days Patients not willing to participate in the study

Design outcomes

Primary

Measure	Time frame
1. To estimate the concentration of neutrophil extracellular traps (NETs) in the pulp blood of mature permanent teeth undergoing pulpotomy in a) symptomatic reversible pulpitis b) symptomatic irreversible pulpitis 2. To estimate the clinical and radiographic outcome of pulpotomy performed in these teeth 3. To determine the association between the above. Timepoint: One year follow up period with recall at 3, 6 months and 1 year.	—

Measure

Time frame

1. To estimate the concentration of neutrophil extracellular traps (NETs) in the pulp blood of mature permanent teeth undergoing pulpotomy in a) symptomatic reversible pulpitis b) symptomatic irreversible pulpitis 2. To estimate the clinical and radiographic outcome of pulpotomy performed in these teeth 3. To determine the association between the above. Timepoint: One year follow up period with recall at 3, 6 months and 1 year.

—

Secondary

Measure	Time frame
1. To estimate the neutrophil counts in the pulp blood of mature permanent teeth undergoing pulpotomy in a) symptomatic reversible pulpitis b) symptomatic irreversible pulpitis 2. To determine the association between the neutrophil counts & outcome of pulpotomy in these teeth. Timepoint: One year follow up period with recall at 3, 6 months & 1 year	—

Countries

India

Contacts

Public ContactDr. Sidhartha Sharma

All India Institute of Medical Sciences (AIIMS), New Delhi

sid.aiims@gmail.com9582542655

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026