Trial to study whether abrupt discontinuation of vasopressin in patients recovering septic shock causes hypotension.

Abrupt Versus Gradual Termination of Vasopressin in Patients on Dual Vasopressors with Septic Shock- Randomised Controlled Trial - TOV

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/064958

Enrollment

212

Registered

2024-04-01

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I952- Hypotension due to drugs

Interventions

Intervention1: Abrupt Termination: When the patient reaches Inj.Noradrenaline at the dose of 0.25 ug/kg/min with MAP more than 70 mmHg, patient will be allocated into two groups. 1. Abrupt termination

Eligibility

Inclusion criteria

Inclusion criteria: Patients with septic shock requiring dual vasopressors

Exclusion criteria

Exclusion criteria: Pregnancy Cardiac dysfunction Peripheral Vascular Disease

Design outcomes

Primary

Measure	Time frame
Incidence of hypotensionTimepoint: At baseline, 1 hour	—

Secondary

Measure	Time frame
Duration of vasopressor from randomization till off vasopressorsTimepoint: At baseline,1 week	—

Countries

India

Contacts

Public ContactDhivya Sundaram

AIIMS Jodhpur

ankuranaesthesia@gmail.com9654045653

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026