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Effect of Tranexamic acid (drug preventing breakdown of blood clots) on the blood loss occurring during debridement (removal of dead and devitalized tissue) in patients with soft tissue infection

Effect of tranexamic acid on intraoperative blood loss in patients undergoing debridement for necrotizing soft tissue infections: A randomized controlled trial. - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/03/064938
Enrollment
76
Registered
2024-03-28
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L089- Local infection of the skin and subcutaneous tissue, unspecified

Interventions

Intervention1: Tranexamic acid 1g: Dose: 1 g Tranexamic acid will be given intravenously over 20 minutes. Frequency: Single dose Duration: Before beginning the surgery. Control Intervention1: Normal

Sponsors

Nivetha Baskaran
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18 to 65 years undergoing debridement for necrotizing soft tissue infection.

Exclusion criteria

Exclusion criteria: Patients on anti-platelets. Patients on anti-coagulants. Pregnancy Patients with a history of MI, TIA, CVA, DVT, and PTE. Patients denying consent. Patients hypersensitive to tranexamic acid or its constituent preservative.

Design outcomes

Primary

MeasureTime frame
To compare the intraoperative blood loss/ square centimeter of the debrided area in patients undergoing debridement for necrotizing soft tissue infection, with and without tranexamic acid.Timepoint: Intraoperative.—

Secondary

MeasureTime frame
To compare the intraoperative fluid administration. To compare the transfusion values (intraoperative and postoperative). To compare the incidence of vascular occlusive events (myocardial infarction, stroke, deep vein thrombosis, and pulmonary thromboembolism). Timepoint: Intraoperative till the time of discharge.—

Countries

India

Contacts

Public ContactNivetha Baskaran

Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research

debasismbbs@gmail.com8763124660

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026