Health Condition 1: I00-I99- Diseases of the circulatory system Health Condition 2: K00-K95- Diseases of the digestive system Health Condition 3: N00-N99- Diseases of the genitourinary system Health Condition 4: J00-J99- Diseases of the respiratory system Health Condition 5: V00-Y99- External causes of morbidity Health Condition 6: O- Medical and Surgical Health Condition 7: C00-D49- Neoplasms
Conditions
Interventions
Intervention1: Pressure controlled ventilation-volume guaranteed: After induction of anaesthesia, patient will be ventilated with pressure controlled ventilation-volume guaranteed with tidal volume of
Sponsors
AIIMS New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients of either sex, undergoing emergency laparotomy under general anaesthesia, with expected duration of more than 2 hours, after giving informed written consent for participation in the study.
Exclusion criteria
Exclusion criteria: 1. Patient refusal 2. Pregnancy 3. BMI of more than 35 kilograms per meter square or less than 18 kilograms per meter square 4. Known pre-existing severe or progressive chronic lung diseases 5. Preoperative diagnosis of pneumonia 6. Deformities of chest wall or thoracic spine 7. Pre-existing significant cardiac, renal or hepatic diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess whether pressure controlled ventilation-volume guaranteed (PCV-VG) has a lesser incidence of postoperative pulmonary complications (POPC) up to 7 days of surgery over a volume controlled ventilation (VCV).Timepoint: Incidence of postoperative pulmonary complications (POPC) at post operative day 0, 1, 2, 3, 4, 5, 6 and 7. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess duration of hospital stay.Timepoint: At hospital discharge.;To assess hospital mortality.Timepoint: At hospital mortality.;To assess intraoperative & postoperative oxygenation status.Timepoint: Intraoperatively and 30 minutes after extubation.;To assess intraoperative lung mechanics i.e. compliance, airway pressures, driving pressures and mechanical power.Timepoint: 10 min after induction, hourly thereafter, and at the end of surgery before extubation.;To assess oxygen free days at day-28 post randomization or till hospital discharge.Timepoint: At day-28 post randomization or till hospital discharge.;To assess the association of mechanical power and postoperative pulmonary complications (POPC).Timepoint: Upto 7 days after surgery.;To assess the preoperative and postoperative lung ultrasound aeration score.Timepoint: Before induction and 30 minutes after extubation.;To characterize the postoperative pulmonary complications according to the European Perioperative Clinical Outcomes definitions.Timepoint: Upto 7 days after surgery. | — |
Countries
India
Contacts
Public ContactNitin Jassal
AIIMS New Delhi
Outcome results
None listed