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To determine the salivary biomarker in children with caries active and caries free children

Quantification and correlation of salivary pH, viscosity and matrix metalloproteinase-8 and matrix metalloproteinase-9 in caries free and caries active children- A randomized clinical trial. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/03/064930
Enrollment
40
Registered
2024-03-28
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K026- Dental caries on smooth surface

Interventions

Intervention1: nil: nil

Sponsors

Dr Gadigi Sampreetha
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Children of 3-6 years of age. 2.Children with 4 and more than 4 active carious lesions. 3.Children with no caries. 4.Parents giving consent for the study.

Exclusion criteria

Exclusion criteria: 1. Children who received fluoride topical application using the last 1 month 2. Children requiring special health care needs. 3. Pulpally involved teeth. 4. Children who were on antibiotic therapy within the past 3 months. 5. Children with genetic diseases or syndromes. 6. Children on any medications.

Design outcomes

Primary

MeasureTime frame
To determine the pH and viscosity in the saliva of children with and without caries using pH meter. To estimate and correlate Matrix metalloproteinase-8 and Matrix metalloproteinase-9 in caries free and caries active children using ELISA method.Timepoint: Baseline—

Secondary

MeasureTime frame
To estimate and correlate Matrix metalloproteinase-8 and Matrix metalloproteinase-9 in Caries free and caries active children Timepoint: Baseline—

Countries

India

Contacts

Public ContactDr Gadigi Sampreetha

RajaRajeswari Dental College and Hospital

umapathygowda@gmail.com9986478744

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026