Thoracoscopic Cryobiopsy versus Forceps Biopsy in patients with undiagnosed exudative pleural effusuion

A randomized trial to compare the diagnostic yield and patient safety profile of Thoracoscopic Flexible Forceps biopsy versus Thoracoscopic Cryo-biopsy in patients with undiagnosed Exudative Pleural Effusion - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/064920

Enrollment

Registered

2024-03-28

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J90- Pleural effusion, not elsewhere classified

Interventions

Intervention1: Thoracoscopic cryo-pleural biopsy: pleural biopsy during thoracoscopy using Erbe 2.4 mm Cryoprobe. (Estimated time 30 mins) Control Intervention1: Forceps Biopsy: Pleural biopsy via tho

Eligibility

Inclusion criteria

Inclusion criteria: Patients with undiagnosed exudative pleural effusion

Exclusion criteria

Exclusion criteria: 1) Transudative effusion 2) empyema 3) haemodynamic instability

Design outcomes

Primary

Measure	Time frame
Diagnostic yield (whether or not diagnosis was made)Timepoint: 5 days (duration of processing of histopathology report)	—

Secondary

Measure	Time frame
change in post procedure pulse rateTimepoint: 1 hour post procedure;change in post procedure blood pressureTimepoint: 1 hour post procedure;comparison of tissue volumeTimepoint: 5 days (duration of processing of histopathology report)	—

Countries

India

Contacts

Public ContactDr J.K. Saini

National Institute of TB and Respiratory Diseases

jk.saini@nitrd.nic.in919818012841

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026