Effect of combination of clomiphene citrate and Letrozole in infertile patients with PCOS

An interventional trial to see the effect of combination of clomiphene citrate and letrozole in infertile women with polycystic ovarian syndrome not responding to either clomiphene citrate or letrozole used as single drug. - NIL

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/064893

Enrollment

Registered

2024-03-28

Start date

Unknown

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N970- Female infertility associated withanovulation

Interventions

Intervention1: clomiphene citrate and letrozole: clomiphene citrate 100 mg and letrozole 2.5 mg will be given for one menstrual cycle (one month) Control Intervention1: not applicable: not applicable

Eligibility

Inclusion criteria

Inclusion criteria: Patients with PCOS not responding to either clomiphene citrate 100 mg or letrzole 2.5 mg

Exclusion criteria

Exclusion criteria: Hypothyroidism Hyperthyroidism Hyperprolactinemia Male factor infertility Tubal factor infertility Uncontrolled Diabetes, History of DVT, liver disease

Design outcomes

Primary

Measure	Time frame
Ovulation will be assessed as primary outcomeTimepoint: Will be assessed on day 21 or after 7 days of dominant follicle formation	—

Secondary

Measure	Time frame
Endometrial thickness Number of follicles Pregnancy rate Multiple pregnancy rate OHSS Any side effects Timepoint: between day 11 TO 18 Endometrial thickness & number of follicles Pregnacy rate after missed periods OHSS & any side effect throughout cycle	—

Countries

India

Contacts

Public ContactShavina Bansal

PGIMER

sgainder@gmail.com9465842261

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026