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Relationship between Human Papilloma Virus infection and head and neck cancer and their features

Association between HPV infection and Head and Neck Squamous Cell Carcinoma and their clinicopathological characteristics - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/03/064864
Enrollment
92
Registered
2024-03-27
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C040- Malignant neoplasm of anterior floor of mouth Health Condition 2: C101- Malignant neoplasm of anterior surface of epiglottis Health Condition 3: C113- Malignant neoplasm of anterior wall of nasopharynx Health Condition 4: C131- Malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect Health Condition 5: C01- Malignant neoplasm of base of tongue Health Condition 6: C050- Malignant neoplasm of hard palate Health Condition 7: C139- Malignant neoplasm of hypopharynx,

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Board of Research in Nuclear Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Biopsy proven HNSCC (primary) of oral cavity, oropharynx, hypopharynx , larynx and sinonasal region.

Exclusion criteria

Exclusion criteria: Past history of any malignancy including that of head and neck region. Immunosuppression due to HIV, chemotherapy, high dose of steroid therapy and patients with primary immunodeficiency diseases such as severe combined immunodeficiency (SCID)

Design outcomes

Primary

MeasureTime frame
Overall incidence of HPV infection amongst patients of Head and Neck Squamous Cell Carcinomas and site-specific distribution of the following mentioned sites will be studied. - Oral cavity - Oropharynx - Hypopharynx - Larynx - Sinonasal region Nodal metastasis between HPV positive and HPV negative tumors of the above mentioned sites. Association of HPV infection with clinicopathological entities in operated cases of HNSCC. Timepoint: 1. Overall incidence of HPV infection amongst patients of Head and Neck Squamous Cell Carcinomas and site-specific distribution of the following mentioned sites will be studied: 2 Years 2. Nodal metastasis between HPV positive and HPV negative tumors of the above mentioned sites: 2 Years. 3. Association of HPV infection with Tumor differentiation, Depth of invasion, Worst pattern of invasion, Lymphovascular invasion and Perineural invasion in operated cases of HNSCC: 2 Years—

Secondary

MeasureTime frame
Correlation of HPV infection and other risk factors in Head and Neck Squamous Cell CarcinomaTimepoint: 2 years—

Countries

India

Contacts

Public ContactPooja Jain

Kasturba Medical College, MAHE, Manipal

suresh.pillai@manipal.edu9901728977

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026