Comparison between pregabalin, melatonin and clonidine as premedication to blunt vital signs during induction of general anaesthesia via laryngoscopy in laparoscopic surgeries. A prospective randomised double blinded study.

Comparison between oral Melatonin, Pregabalin & Clonidine as premedication for attenuation of hemodynamic responses to laryngoscopy & intubation in laparoscopic surgeries; A prospective randomised double blinded study. - Cbompc

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

CTRI

Registry ID

CTRI/2024/03/064816

Enrollment

Registered

2024-03-27

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: Oral Drug pregabalin, melatonin and clonidine: Oral drug administration as premedication before laryngoscopy and intubation. Control Intervention1: Oral drug administration: Oral drug a

Eligibility

Inclusion criteria

Inclusion criteria: Patients posted for elective surgery under general anaesthesia with endotracheal tube. Patients under American society of Anaesthesiologists physical status 1&2. Patients with BMI less than 35kg/m2

Exclusion criteria

Exclusion criteria: Patients under ASA 3 & 4. Patients with difficult airway. Patients in whom other forms of regional anesthesia is also used. Patients with known allergy to Melatonin, Pregabalin or clonidine. Patient not willing to give consent for the study.

Design outcomes

Primary

Measure	Time frame
Compare the blunting of hemodynamic response, sedation scores and post op analgesia with melatonin, pregabalin and clonidine in laparoscopic surgeries.Timepoint: 1 minute, 3 minute, 5 minute and 10 minute	—

Secondary

Measure	Time frame
Observe any side effects associated with the drugs and ease of intubation.Timepoint: Post op.	—

Countries

India

Contacts

Public ContactSayed sahil ahmed

IMS and Sum hospital

Shahilahmed94@gmail.com7205817340

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026