Comparing effect of two antiseptics in the routine management of fungal ulcer

Comparison of adjuvant 0.02% Chlorhexidine gluconate with 1% Povidone-Iodine in the management of fungal keratitis: A randomized controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/064803

Enrollment

Registered

2024-03-27

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H160- Corneal ulcer

Interventions

Intervention1: 0.02% Chlorhexidine gluconate: Duration- 3 weeks or till reepithelization, Topical, 6times/ day Intervention2: 1% Povidone-Iodine: Duration- 3 weeks or till reepithelization, Topical ad

Eligibility

Inclusion criteria

Inclusion criteria: Evidence of fungal infection on smear microscopy or in vivo confocal microscopy

Exclusion criteria

Exclusion criteria: Ulcers warranting immediate surgical intervention Impending perforation, Perforated ulcer Mixed OR Bacterial infective keratitis Endophthalmitis Previous keratoplasty in affected eye Known allergy to study medications

Design outcomes

Primary

Measure	Time frame
Time to ulcer healingTimepoint: Day 0, day 3, 7, 14, 21, 60 and 90	—

Secondary

Measure	Time frame
Best spectacle-corrected visual acuityTimepoint: 3 months;infiltrate size and depthTimepoint: day 0, day 3, 7, 14, 21, 60 and 90;Microbiological cure rateTimepoint: day 7;Morphological changes on in vivo confocal microscopyTimepoint: day 0, 7, 90;Need for therapeutic penetrating keratoplastyTimepoint: day 0,3,7,14,21,60, 90;scar sizeTimepoint: 3 months;Time to re-epithelializationTimepoint: Time to re-epithelialization	—

Measure

Time frame

Best spectacle-corrected visual acuityTimepoint: 3 months;infiltrate size and depthTimepoint: day 0, day 3, 7, 14, 21, 60 and 90;Microbiological cure rateTimepoint: day 7;Morphological changes on in vivo confocal microscopyTimepoint: day 0, 7, 90;Need for therapeutic penetrating keratoplastyTimepoint: day 0,3,7,14,21,60, 90;scar sizeTimepoint: 3 months;Time to re-epithelializationTimepoint: Time to re-epithelialization

—

Countries

India

Contacts

Public ContactArpita Kulshrestha

PGIMER, CHANDIGARH

pcgpgi@gmail.com9876764629

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026