Role of Intravenous Ondansetron and Hydrocortisone combination in prevention of headache after spinal anaesthesia in pregnant women undergoing caesarean section

Role of Ondansetron and Hydrocortisone combination in prevention of PDPH after spinal anaesthesia for caesarean section - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/064741

Enrollment

100

Registered

2024-03-26

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O80- Encounter for full-term uncomplicated delivery

Interventions

Intervention1: Ondansetron and Hydrocortisone: Participants in this group will receive single dose intravenous Ondansetron 4 mg and intravenous Hydrocortisone 100 mg after the baby delivery. Control I

Eligibility

Inclusion criteria

Inclusion criteria: Parturient posted for elective caesarean sections with American Society of anaesthesiologists physical status 2, with Body mass index of less tha 35 kg/m2

Exclusion criteria

Exclusion criteria: Parturient unwilling to participate in study, with history of chronic steroid use, history of migraine, preeclampsia, eclampsia, gestational diabetes mellitus

Design outcomes

Primary

Measure	Time frame
To compare the incidence of Post dural puncture headache at 24 hrs, 48hrs, 72 hrs and follow up upto a week in parturient who have received the prophylactic combination of ondansetron and Hydrocortisone versus the control group who have not received any of the above prophylactic medicationsTimepoint: To compare the incidence of Post dural puncture headache at 24 hrs, 48hrs, 72 hrs and follow up upto a week in parturient who have received the prophylactic combination of ondansetron and Hydrocortisone versus the control group who have not received any of the above prophylactic medications	—

Measure

Time frame

To compare the incidence of Post dural puncture headache at 24 hrs, 48hrs, 72 hrs and follow up upto a week in parturient who have received the prophylactic combination of ondansetron and Hydrocortisone versus the control group who have not received any of the above prophylactic medicationsTimepoint: To compare the incidence of Post dural puncture headache at 24 hrs, 48hrs, 72 hrs and follow up upto a week in parturient who have received the prophylactic combination of ondansetron and Hydrocortisone versus the control group who have not received any of the above prophylactic medications

—

Secondary

Measure	Time frame
To compare incidence of Postoperative Nausea and vomiting between the two groupsTimepoint: occurrence of nausea and vomiting till 3 days postop	—

Countries

India

Contacts

Public ContactDr Laxmi Shenoy

Kasturba Medical College Hospital, Manipal

drlaxmishenoy@gmail.com9448911261

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026