Health Condition 1: K746- Other and unspecified cirrhosis ofliver
Conditions
Interventions
Intervention1: Plasma Exchange with Standard Medical Treatment: Plasma Exchange along with all patients will receive salt restricted, high protein diet (1.5 g per kg of proteins) either enterally or p
Sponsors
Institute of Liver and Biliary Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 18 to 60 years 2. Severe alcoholic hepatitis with DFmore than 80 and less than 120 or MELD more than 30 3. No liver transplant option available in near future(for atleast 1 month) 4. Patient able to bear the cost of Plasma exchange by himself/herself
Exclusion criteria
Exclusion criteria: 1. Active sepsis 2. S creatinine more than 1.5mg per dl 3. Chronic kidney disease 4. Pregnancy 5. HCC or any other malignancy 6. Active Bleeding 7. Allergic to replacement fluid (FFP) in TPE 8. Severe Hypocalcemia (less than 7.6 mg per dl) 9. Failure to give consent 10. Financial issues to bear cost of Plasma exchange
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver transplant free survival at 28 days, 90 days.Timepoint: 28 days, 90 days. | — |
Secondary
| Measure | Time frame |
|---|---|
| End of study period (90 Days)Timepoint: 90 days;Frequency of decompensation events on follow up periodTimepoint: 28 days;Mortality at 28 daysTimepoint: 28 days;Post therapy assessment in the form of clinical improvement (hepatic encephalopathy, ascites , improvement in jaundice)(both ascites and HE if present)Timepoint: 28 days | — |
Countries
India
Contacts
Public ContactDr Shasthry S M
Institute of Liver and Biliary Sciences
Outcome results
None listed