Studying effect of propofol and ketamine as induction agents in electro convulsive therapy in patients with depression.

A comparative study of effectiveness of propofol and ketamine as induction agent for electro convulsive therapy in patient with severe depression. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/064547

Enrollment

Registered

2024-03-20

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F332- Major depressive disorder, recurrent severe without psychotic features

Interventions

Control Intervention1: Ketamine: Effectiveness of ketamine as induction agent in electro convulsive therapy in patients with severe depression duration of data collection -till 6 weeks after ect Cont

Eligibility

Inclusion criteria

Inclusion criteria: Patients of both sexes between age 18-65 years. Patients with severe depressive disorder requiring electro convulsive therapy. Patients with American Society of Anaesthesiology (ASA) physical status l & ll .

Exclusion criteria

Exclusion criteria: Pregnant females and lactating mothers. Patients on chronic opiate use such as tramadol. Known allergies to study drugs. Patients with hypertension, IHD and other heart diseases.

Design outcomes

Primary

Measure	Time frame
A) 1)Mean blood pressure 2)Heart rate 3)Oxygen Saturation B) 1)Spontaneous eye opening 2)Obeying verbal commands C) MADRS(Montgomery Asberg Depression Rating Scale)Timepoint: A) 2min before premedication 2min after induction 5min, 10min, 15min, 20min after giving shock and onset of seizures B) 0min, 5min,10min, 15min post ect C) 1st & 2nd week post ect	—

Secondary

Measure	Time frame
Incidence & severity of post ect agitationTimepoint: 15 min post ect;Incidence & severity of post ect myalgiaTimepoint: 6hrs & 12hrs post ect;Seizure durationTimepoint: 10 min after induction	—

Countries

India

Contacts

Public ContactSasturkar Vasanti Mukund

MGM Medical College and Hospital

vasantims@rediffmail.com9370668196

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026