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Effectiveness of Magnesium and Lignocaine in Reducing Stress During Airway Procedures: A Clinical Trial

TO STUDY THE EFFICACY OF INTRAVENOUS MAGNESIUM SULPHATE WITH AND WITHOUT LIGNOCAINE SPRAY IN ATTENTUATING THE PRESSOR RESPONSE TO LARYNGOSCOPY AND INTUBATION - NIL

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/03/064545
Enrollment
88
Registered
2024-03-20
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: with intravenous magnesium sulphate (30mg/kg): to assess the pressor response attenuation during intubation with intravenous magnesium sulphate (30mg/kg) given before induction of gener

Sponsors

Mahatma Gandhi medical college
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. patients belonging to ASA grade I, II. 2. Patients posted for surgery under general anaesthesia 3. AGE - 18-60 years of age 4. SEX - Male and Female

Exclusion criteria

Exclusion criteria: history of allergic to local anaesthetic agents Patients with coronary artery disease Difficult airway hypertensive patients on two or more medications BMI greater than 30

Design outcomes

Primary

MeasureTime frame
To assess and compare the Heart rate and blood pressure variation due to pressor response between the two study groups. Timepoint: To assess baseline heart rate and blood pressure and the variations after the administration of the test drug, during intubation, 2 minutes, 4 minutes, 6 minutes, 8 minutes and at 10 minutes after intubation.

Secondary

MeasureTime frame
To assess sedation score post extubation using Ramsay sedation scale between the two groups.Timepoint: to be assessed before shifting the patient to recovery room.

Countries

India

Contacts

Public ContactDr Hemanth Kumar V R

Mahatma Gandhi medical college, Pondicherry

drvrhk@gmail.com9003550553

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026