A clinical study comparing outcome of regenerative root canal treatment with and without chitosan loaded triple antibiotic paste.

Evaluation of Regenerative Potential of Pulp in Necrotic Mature teeth using Chitosan-Loaded Triple Antibiotic paste: A Randomised clinical trial. - NA

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/064482

Enrollment

Registered

2024-03-20

Start date

Unknown

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Regenerative procedure with Triple antibiotic paste: Local anesthesia will be delivered followed by rubber dam isolation, straight-line access cavity was performed. The working length w

Eligibility

Inclusion criteria

Inclusion criteria: 1. patients in the age range of 18–30 years without systematic disease/allergic reactions 2. Nonvital single- rooted teeth (anterior or premolars) encasing 1 root canal with mature roots (closed apices) and a periapical lesion score =3 according to Ostravik et al. Score 1: Normal periapical structure Score 2: Small changes in bone structure Score 3: Changes in bone structure with mineral loss Score 4: Periodontitis with well-defined radiolucency Score 5: Severe periodontitis with exacerbating factors

Exclusion criteria

Exclusion criteria: 1. Medically compromised patients (with immunosuppressive/systemic diseases, patients on medications) - periodontologically compromised teeth. 2. Endodontically treated teeth 3. Teeth with periapical lesions more than 5 mm in diameter. 4. Patients who refuse to participate. 5. Anatomical variations leading to inability to reach the full working length.

Design outcomes

Primary

Measure	Time frame
To evaluate the regenerative potential of pulp in necrotic mature teeth with and without chitosan loaded triple antibiotic paste.Timepoint: The outcome will be assessed at 6months and 1 year .	—

Secondary

Measure	Time frame
Vitality of toothTimepoint: the vitality of the tooth will be assessed with electric pulp testing device after 6 months and 1 year of the treatment	—

Countries

India

Contacts

Public ContactDr Asiya Sameer Mujawar

M.A.Rangoonwala college of dental science and research centre

drasiyashaikh786@gmail.com9552978658

Outcome results