Health Condition 1: K228- Other specified diseases of esophagus
Conditions
Interventions
Control Intervention1: Melatonin receptors MT1 and MT2: Comparing the expression vs non-expression of melatonin receptors MT1 and MT2 in the esophageal carcinoma tissue samples.
Sponsors
All India Institute of Medical Sciences, New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: • Patients diagnosed with Ca Esophagus (squamous cell carcinoma morphology) above 18 years of age irrespective of stage of the disease. • Preoperative biopsy tissues or tissues from the postoperative specimens
Exclusion criteria
Exclusion criteria: . Age 80 years. . Other morphological types of Esophageal carcinoma . Patients with ECOG PS >2 (in patients planned for curative resection) . Preoperative / postoperative samples found negative for malignancy in histopathological examination . Patients found inoperable intra operatively . Patients who had complete clinical response following neo adjuvant chemotherapy/ chemoradiation . Not willing to participate or follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective is to study the expression of melatonin MT1 and MT2 receptors in the Ca esophagus. The expected outcome of the study is to establish the expression pattern of melatonin receptors MT1 and MT2 in carcinoma of the esophagus and to determine their correlation with the tumor grade. Overall, the study aims to provide insight into the potential of melatonin as a therapeutic agent as well as a prognostic marker for esophageal cancer.Timepoint: 0-4 MONTHS: procurement of consumables 5-18 MONTHS: collection of tissue samples and implementation of the lab procedures. 18-24 months: Analysis and compilation of results, writing the manuscript and presentation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Studying the expression of melatonin MT1 & MT2 receptors by Immunohistochemistry & tissue ELISA & comparing their expression patterns with the tumor grade.Timepoint: 0-4 MONTHS: procurement of consumables 5-18 MONTHS: collection of tissue samples & implementation of the lab procedures. 18-24 months: Analysis & compilation of results, writing the manuscript & presentation. | — |
Countries
India
Contacts
Public ContactArthi Ganapathy
All India institue of Medical Sciences, New Delhi
Outcome results
None listed