To compare 3 surgical devices plastic clip, commercially available loops and hand made knot technique to secure appendiceal base in terms of surgical time, cost, safety ,surgeons preference and technical ease

Comparison of stump ligation time, safety and cost-effectiveness between HOLP, Endo loop and Roader’s knot for appendectomy in uncomplicated acute appendicitis: a randomized controlled trial at a single centre - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/064477

Enrollment

114

Registered

2024-03-20

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K353- Acute appendicitis with localizedperitonitis Health Condition 2: K00-K95- Diseases of the digestive system

Interventions

Intervention1: hemlock polymer clips: stump ligation by hemlock polymer clips Intervention2: catgut endoloop: stump ligation by catgut endoloop Intervention3: vicryl suture knot: stump ligation by Ro

Eligibility

Inclusion criteria

Inclusion criteria: 2. Patients scheduled to undergo emergency laparoscopic appendectomy for acute uncomplicated appendicitis

Exclusion criteria

Exclusion criteria: 1. Patient having preoperative evidence of perforated or gangrenous appendicitis 2. Patients with friable and unhealthy base 3. Patients in whom technique of stump closure will be changed due to intraoperative difficulty 4. Patients who get converted to open appendectomy 5. Patients in whom another device such as metal clips, intracorporeal suturing or stapler used as stump closure method 6. Patients in whom procedure is performed by a surgeon that does not belong to the investigator/co-investigator s of the study

Design outcomes

Primary

Measure	Time frame
To compare total stump ligation time between HOLP clip, Roader’s knot and Endoloop for the closure of the appendix base during laparoscopic appendectomyTimepoint: at baseline	—

Secondary

Measure	Time frame
c) Any operative complication using Clavin-Dindo classificationTimepoint: 24 month;a) Cost effectiveness of the techniqueTimepoint: 24 months;b) Grading of technical ease of the procedure by the operating surgeon using 5-point Likert scale questionnaireTimepoint: 24 months	—

Countries

India

Contacts

Public ContactDr Agrawal Kavita Khemchand

Dr.B.R.Ambedkar State Institute of Medical Sciences, Mohali

drkavitaagrawal@gmail.com7087438617

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026