Which is a better reversal agent, Sugammadex or Neostigmine with Glycopyrolate in case of Laproscopic Cholecystectomy?

Comparative study of Sugammadex with Neostigmine and Glycopyrolate as a reversal agent in Laparoscopic Cholecystectomy - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/064392

Enrollment

120

Registered

2024-03-19

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Sugammadex: Inj Sugammadex 2mg/kg IV given when TOF count is 2 Control Intervention1: Neostigmine and Glycopyrolate: Inj Neostigmine and Glycopyrolate 0.08mg/kg IV given when TOF count

Eligibility

Inclusion criteria

Inclusion criteria: ASA status type I or II Adult patients without predicted difficult airway Elective Surgery requiring General Anaesthesia Informed consent by the Patient

Exclusion criteria

Exclusion criteria: Patient unwilling ASA status type III or IV

Design outcomes

Primary

Measure	Time frame
To determine the duration from administration of sugammadex or neostigmine to recovery from muscle relaxation recorded on train of four ratio to 0.9.Timepoint: from induction of anaesthesia to recovery.	—

Secondary

Measure	Time frame
1. To compare the length of stay in the operating room & post – anaesthesia care unit following administration of sugammadex & neostigmine.Timepoint: 1. from the time of induction to shifting of patient to ward after complete recovery in post anaesthesia care unit. ;To compare safety profile by assessing adverse events like post operative nausea & vomiting ,shivering, hypoxia & hypotension.Timepoint: From the time of shifting to post anaesthesia care unit then every 5 minutes till shifting to ward after complete recovery.	—

Measure

Time frame

1. To compare the length of stay in the operating room & post – anaesthesia care unit following administration of sugammadex & neostigmine.Timepoint: 1. from the time of induction to shifting of patient to ward after complete recovery in post anaesthesia care unit. ;To compare safety profile by assessing adverse events like post operative nausea & vomiting ,shivering, hypoxia & hypotension.Timepoint: From the time of shifting to post anaesthesia care unit then every 5 minutes till shifting to ward after complete recovery.

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Countries

India

Contacts

Public ContactDr Sourabh Kumar

Rajendra Institute of Medical Sciences Ranchi

shiopriye@gmail.com9986743162

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026