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Comparing recovery profile of two independent inhalational anaesthetic agents Desflurane and Sevoflurane in patients undergoing Transnasal Trans-sphenoidal surgery for pituitary tumors with the help of Bispectral index which is a tool to monitor and analyze the depth of anaesthesia

Comparison of Bispectral index guided recovery profile of Desflurane with Sevoflurane anaesthesia in Transnasal Trans-sphenoidal surgery for pituitary tumors - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/03/064312
Enrollment
40
Registered
2024-03-18
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D352- Benign neoplasm of pituitary gland

Interventions

Intervention1: Desflurane Route of administration - inhalation Dose- can be titrated to keep the MAC upto 1: Bispectral index guided recovery profile of Desflurane anaesthesia in Transnasal Trans-sph

Sponsors

ABVIMS and Dr.RML hospital, New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult patients:18-65 years of age 2. ASA Grade I and Grade II 3. Patient posted for elective Transnasal trans-sphenoidal surgery for pituitary tumors

Exclusion criteria

Exclusion criteria: 1. History of previous pituitary surgery 2. Patients with GCS less than 15 3. Patients with psychiatric disorders with history of any drug abuse 4. Poorly controlled Hypertension/Diabetes Mellitus 5. Ischemic heart disease 6. Pituitary apoplexy 7. History of allergy to any of the planned anaesthetic medications for the study.

Design outcomes

Primary

MeasureTime frame
Recovery profile by using BIS values Timepoint: 1.Time taken from the discontinuation of maintenance anaesthetic agent to the BIS value to reach 70 for clinical recovery (mins) 2.Time taken from the administration of reversal to the BIS value to reach 85-90 for Extubation (mins)—

Secondary

MeasureTime frame
1.Hemodynamic parameters (Heart rate in beats/min, MAP in mmHg) 2.The total top up increments of rescue anaesthetic agent-propofol (1mg/kg) during maintenance when the BIS value exceeds more than 60. Timepoint: Heart rate and Mean arterial pressure •At baseline •At pre-intubation •At post-intubation •At BIS value of 55 •At BIS value of 70 (Recovery) •At BIS value of 85-90 (Extubation)—

Countries

India

Contacts

Public ContactChandramowli M

ABVIMS and Dr.RML hospital

alkagupta_rml@yahoo.co.in9871653335

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026