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Comparison of blood flow changes in brain with different anaesthetic drugs in patients with Moya Moya disease and undergoing bypass surery.

Intraoperative distal MCA flow velocity patterns during bypass procedures in Moya Moya disease patients- A prospective study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/03/064248
Enrollment
60
Registered
2024-03-15
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Hypercarbia, hypocarbia, hypertension.(within the physiological limits and range): Hypercarbia-To increase end tidal carbon dioxide values, ventilatory settings are adjusted by reducing

Sponsors

NIMHANS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients with Moya Moya disease aged 2yrs to 65 years, undergoing direct revascularization surgery ; Superficial Temporal Artery- Middle Cerebral Artery bypass surgery( STA – MCA bypass surgery) with American Society of Anaesthesiology Physical Status ( ASA PS) I and II will be included in the study.

Exclusion criteria

Exclusion criteria: Proposed surgical procedure is modified (direct to indirect) Pregnant women. Those patients who refuse to give consent Patients with Ischaemic Heart Disease (IHD)

Design outcomes

Primary

MeasureTime frame
To compare intraoperative distal MCA cerebral blood flow velocities in Moya Moya Disease patients receiving Ioflurane, Sevoflurane, Desflurane, Propofol anaesthesia during direct revascularisation (STA-MCA Bypass) surgery.Timepoint: Preanastomosis and post anastomosis—

Secondary

MeasureTime frame
To observe the changes in the distal MCA mean blood flow volume before & after micro-anastomosis under different anaesthesia. To compare the intraoperative mean distal MCA CBFV changes during hypercapnia prior to & during hypocapnia after micro anastomosis. To compare the changes in mean distal MCA CBFV following blood pressure augmentation after anastomosis & correlation with post-operative hyperaemic complications. To observe the changes in regional cerebral oxygenation (rSO2) before & after anastomosis & correlation with post-operative ischemic & hyperaemic complications. Timepoint: Hypercapnea-Before hypercapnia & at 5 min after achieving hypercapnia Hypocapnia-Before hypocapnia & at 5 min after achieving hypocapnia BP augmentation-Before BP augmentation and at 5 min after desired increase in MAP being achieved Cerebral oximetery-Before & after anastomosis Baseline, Post intubation, post hypercapnic challenge, post hypocapnic challenge, post hypertensive challenge, Post clamping, Post Anastomosis , Surgery end & Before reversal—

Countries

India

Contacts

Public ContactDr M Radhakrishnan

NIMHANS

mrks1974@gmail.com9480829719

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026