Health Condition 1: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx
Conditions
Interventions
Intervention1: Peritumoral injection of collagenous nanoparticle: One time injection of collagenous nanoparticle with dose 0.5 ml (1-2 mCi) at route peritumoral in selected cases of oral cavity squamo
Sponsors
Department of Otorhinolaryngology, Head and Neck surgery AIIMS New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients above 18 years of age 2. Histologically proven squamous cell carcinoma of oral cavity 3. T1-T4 as per 8th AJCC 4. Clinically and radiologically N0 status in the neck 5. Patients giving consent for surgical modality of treatment.
Exclusion criteria
Exclusion criteria: 1. Patients who are poor candidates for general anesthesia 2. Presence of neck metastasis or distant metastasis 3. Patients with a history of recurrent head and neck malignancies. 4. Previous surgery or radiotherapy to head and neck
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Sensitivity of sentinel lymph node mapping by use of Sulphur colloid and lymphoscintigraphy & SPECT imaging will be compared with selective neck dissection as gold standard. 2.Sensitivity of sentinel lymph node mapping by use of DC-Col NP and lymphoscintigraphy & SPECT imaging will be compared with selective neck dissection as gold standard. 3.will calculate Negative predictive value 4.will assess Kinetics flow along the lymphatic pathways Timepoint: 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The diagnostic accuracy of both the techniques will be compared with each other. 2. Toxicity in both groups will be evaluated & compared. Timepoint: 8 weeks | — |
Countries
India
Contacts
Public ContactNongthombam Surjalata Devi
AIIMS DELHI
Outcome results
None listed