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Comparison of two drugs tablet pregabalin via oral route versus intravenous dexmedetomidine as in reducing blood pressure changes in patients undergoing general anesthesia during surgeries.

A comparative study on the efficacy of oral Pregabalin versus intravenous Dexmedetomidine as premedication on hemodynamic response during laryngoscopy in elective surgeries - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/03/064189
Enrollment
100
Registered
2024-03-15
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: -

Interventions

Intervention1: oral pregabalin 75 mg once : premedication before induction with general anesthesia Control Intervention1: Intravenous dexmedetomidine 0.5 mcg/kg once: premedication before induction wi

Sponsors

Dr Radhakrishnan A professor
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age groups between 18 and 65 years,   2. American Society of Anesthesiologists physical status Class I or II 3. Elective surgeries requiring general anesthesia

Exclusion criteria

Exclusion criteria: 1.Patients with medical disorders like cardiovascular, renal and liver diseases 2.Patients with anticipated difficult airway   3.Patients who are already taking pregabalin or other anticonvulsants and sedatives, beta  blockers .  4.Patients who are not willing to participate

Design outcomes

Primary

MeasureTime frame
Mean arterial pressure, Blood pressure, Heart rateTimepoint: Baseline,30 mins after oral drug , during intubation,1 min,3 min , 5 min, 10 min , every 15 min after that till 4 hours

Secondary

MeasureTime frame
any adverse effects of the drugTimepoint: throughout surgery

Countries

India

Contacts

Public ContactDr Sindhuja M

Sri venkateshwaraa medical college hospital and research centre, Ariyur, Puducherry

rkpuduvai@gmail.com8825778958

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026