Health Condition 1: G998- Other specified disorders of nervous system in diseases classified elsewhere
Conditions
Interventions
Intervention1: Sugammadex: Drug Inj Sugammadex 2mg/kg will be given once over 15-30 seconds for reversal of rocuronium induced neuromuscular blockade in adult neurosurgical patients
Control Interven
Sponsors
AIIMS
Eligibility
Inclusion criteria
Inclusion criteria: 1. ASA grade 1&2 patients, aged 18-65 yrs scheduled for elective neurosurgery and planned for extubation immediately following surgery will be included for the study.
Exclusion criteria
Exclusion criteria: The following patients will be excluded from the study: 1. Refusal of consent. 2. Patients with Glasgow Coma Scale (GCS) 3. Patients having psychotic disorders 4. Pregnant patients 5. Patients intended for postoperative mechanical ventilation or not extubated after surgery 6. Known or suspected allergy to study drugs 7. Patients with uncontrolled hypertension, uncontrolled D.M or heart disease 8. Patient with history of late recovery from anaesthesia previously
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| time taken from the point of administration of reversal to extubationTimepoint: After surgery,the time point of administration of reversal is taken as 0 minutes.From 0 minutes till extubation the time duration will be noted. | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic arterial pressure, diastolic arterial pressure, mean arterial pressure (MAP), heart rate (HR), oxygen saturation(SpO2), temperature, end tidal carbon dioxide (EtCO2), bispectral index(BIS), TOF count and TOF ratio and PTCTimepoint: baseline, induction, intubation, 10 minutes after intubation, incision, closure, stopping of fentanyl, rocuronium, stopping of propofol/inhalational, during reversal administration, at extubation, 1 min after, 2 min after, 5 minutes after and 10 minutes after extubation | — |
Countries
India
Contacts
Public ContactDr Suman Sokhal
AIIMS
Outcome results
None listed