A study which aims to reduce vomiting and feeling of vomiting in patients after operation of gallbladder by laparoscopic approach, one group of patients will have dexamethasone by intravenous route and the other group by giving the drug inside the abdomen during operation.

Comparison of effect of intraperitoneal versus intravenous dexamethasone on postoperative nausea, and vomiting after laparoscopic cholecystectomy: A prospective, randomised, double blinded study - NIL

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/064103

Enrollment

100

Registered

2024-03-13

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intraperitoneal Dexamethasone: Intraperitoneal group will receive 8 mg of Intra Peritoneal dexamethasone once and 2 ml of IntraVenous normal saline once as the placebo Control Interve

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA grade I & II. 2. Female patients. 3. Patients undergoing laparoscopic Cholecystectomy. 4. Patients giving valid consents

Exclusion criteria

Exclusion criteria: 1. Patients with severe cardio-respiratory disease 2. Patients with hepatic & renal disease 3. Patients with neurologic disorder 4. Patients with endocrine disorder 5. Patients who will not give valid consent. 6. Patients with psychiatric problem 7. Patients with H/O dexamethasone allergy. 8. Patients with pregnancy

Design outcomes

Primary

Measure	Time frame
Incidence and severity of post operative nausea and vomitingTimepoint: 2, 4, 8, 12, and 24 hours after laparoscopy.	—

Secondary

Measure	Time frame
1. To compare the requirement of rescue antiemetic between the two groups. 2. To compare the requirement of rescue analgesic between the two groups during the first 24hour 3. To compare the hemodynamic changes between the two groups in intra operative and post operative period during the first 24hour. 4.To study the side effects if any attributable to drugs Timepoint: 2, 4, 8, 12, and 24 hours after surgery	—

Measure

Time frame

1. To compare the requirement of rescue antiemetic between the two groups. 2. To compare the requirement of rescue analgesic between the two groups during the first 24hour 3. To compare the hemodynamic changes between the two groups in intra operative and post operative period during the first 24hour. 4.To study the side effects if any attributable to drugs Timepoint: 2, 4, 8, 12, and 24 hours after surgery

—

Countries

India

Contacts

Public ContactDr Mizanul Haque

Midnapore Medical College & Hospital

mandiarunkr87@gmail.com8697633923

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026