Health Condition 1: E301- Precocious puberty
Conditions
Interventions
Intervention1: NIL: NIL
Sponsors
Department of Health Research
Eligibility
Inclusion criteria
Inclusion criteria: Cases will be identified as children with either gender who present with early or precocious puberty defined in girls as onset of thelarche, pubarche or adrenarche before 8 years of age and in boys as increase in testicular volume greater than 4mL, pubarche or adrenarche before 9 years of age. Children labeled as idiopathic precocious puberty (due to both central and peripheral causes) will be included as Cases.
Exclusion criteria
Exclusion criteria: 1.Children born small for gestational age defined as birth weight below 10th centile. 2.Children with organic cause of early or precocious puberty like intracranial malformation, infection, tumors or congenital adrenal hyperplasia or gonadal tumors. 3.Children previously diagnosed with any hormonal disorder or on any steroid drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urinary and serum levels of plasticizer like bisphenol-A, plasma phthalate in cases and controlsTimepoint: Single point | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between bisphenol-A, plasma phthalate levels & serum FSH, LH & kisspeptin expression between control & cases Timepoint: Single point;Correlation between plasticizer levels & anthropometry & serum leptin levelsTimepoint: Single point | — |
Countries
India
Contacts
Public ContactDr Binita Goswami
Maulana Azad Medical College
Outcome results
None listed