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use of tablet tolvaptan in preventing disease during surgery named TURP

efficacy of tolvaptan in prevention of TURP syndrome: A prospective randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/03/064070
Enrollment
70
Registered
2024-03-13
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N00-N99- Diseases of the genitourinary system

Interventions

Intervention1: tab Tolvaptan 15mg given orally only once 2hrs before surgery only once: drug used to prevent TURP syndrome tab Tolvaptan 15mg given orally only once 2hrs before surgery only once Contr

Sponsors

Ramya kamlekar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status 1,2 undergoing elective TURP surgery under spinal anesthesia prostate gland volume more than 45gm

Exclusion criteria

Exclusion criteria: General anesthesia, chronic/acute kidney dysfunction, pre-existing uncontrolled cardiovascular and pulmonary disease, use of diuretics, patient not consenting for study, contraindication for spinal anesthesia

Design outcomes

Primary

MeasureTime frame
single dose of tolvaptan in preventing TURP syndrome and decrease in serum sodium levels compared to control groupTimepoint: 1) before giving tolvaptan on the day of surgery 2) one hour after resection 3) one hour after surgery—

Secondary

MeasureTime frame
decrease in serium sodium levels in both groupsTimepoint: 1) before giving tolvaptan on the day of surgery 2) one hour after resection 3) one hour after surgery—

Countries

India

Contacts

Public ContactRamya Lakshmi Kamlekar

ESIC Superspeciality hospital, hyderabad

dr.prernabhola@gmail.com9032225503

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026