Health Condition 1: - Health Condition 2: S069- Unspecified intracranial injury
Conditions
Interventions
Intervention1: Ketofol for ICU sedation: IV infusion of ketofol (1:4)will be given
Propofol at the rate of 0.5
mg/kg bolus followed by maintenance at 25-50 mcg/kg/min (1.5-3mg/kg/hr) and
Ketamine at the rate of 0.125mg/kg bolus followed by maintenance at 0.375-0.75 mg/kg/hr. Sedatio
Sponsors
AIIMS
Eligibility
Inclusion criteria
Inclusion criteria: Severe traumatic brain injury patients admitted into Neuro Trauma ICU within 48 hours after the trauma. 1)Patients with a primary diagnosis of isolated severe TBI GCS 3-8 2) Patients between 18-65 years of age and of either sex
Exclusion criteria
Exclusion criteria: 1) Patients with persistent GCS of 3 with bilateral fixed dilated pupils after initial resuscitation. 2) Also includes those patients who underwent decompressive craniectomy before ICU admission 3) In the absence of a guardian to give consent for the study 4) Life-threatening polytrauma 4) Patients in shock requiring vasopressor support at ICU admission 5) Pre-existing brain disease 6) Pregnancy 7) Patients allergic to drugs being used for sedation 8) Patients with deranged hepatic and renal parameters
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the levels GFAP and UCH L1 levels after 48 hrs of ICU admission using ketofol versus fentanyl and midazolam as sedationTimepoint: To compare the levels GFAP and UCH L1 levels after 48 hrs of ICU admission using ketofol versus fentanyl and midazolam as sedation | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the levels GFAP and UCH L1 levels after 5 days of ICU admission 2) Duration of ICU and Hospital stay Timepoint: after 5 days of ICU admission | — |
Countries
India
Contacts
Public ContactDr Suman Sokhal
AIIMS
Outcome results
None listed