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Comparative Evaluation of Anaesthetic Efficacy and Pain on Injection of Buffered and Unbuffered 4% Articaine with 1:100000 Adrenaline for Mandibular Molar Extractions using Infiltrations techniques

Comparative Evaluation of Anaesthetic Efficacy and Pain on Injection of Buffered and Unbuffered 4% Articaine with 1:100000 Adrenaline for Mandibular Molar Extractions using Infiltrations techniques- A Prospective Randomized Double Blind Study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/03/064030
Enrollment
160
Registered
2024-03-12
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K029- Dental caries, unspecified

Interventions

Intervention1: articaine with 1:100000 adrenaline: local anesthetic agent with vasopressor Control Intervention1: articaine with 1:100000 adrenaline + sodium bicarbonate: buffered articaine that it 8.

Sponsors

shubham prajapati
Lead Sponsor
MGM dental college
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Participant in the age group 18-60 years of age. Participant indicated for mandibular molar extraction.

Exclusion criteria

Exclusion criteria: 1. Participant with known allergy to amide type of local anaesthetic agent and adrenaline. 2. Participants having active local infections, abscessor any other lesion at the injection site. 3. Participant with systemic co-morbidities that would preclude adminstration of local anaestheisa or adrenaline ( eg- disorders of liver, kidney, cardiovascular system, etc) or are contraindication of extraction. 4. Participant taking medications such as sedative, narcotics, antidepressants or antianxiety medications 1 week prior to procedure and NSAIDS 3 days prior to procedure. 5. Pregnancy. 6. Alcohol consumption 48 hours before of study. 7. Participants not willing to participate in the study.

Design outcomes

Primary

MeasureTime frame
There is a difference in anaesthetic efficacy between buffered and nonbuffered 4% articaine with 1:100000 for mandibular molar extractions using infiltration technique. Timepoint: 1-immediate

Secondary

MeasureTime frame
There is a difference in pain on injection between buffered & nonbuffered 4% articaine with 1:100000 for mandibular molar extractions using infiltration techniqueTimepoint: 1

Countries

India

Contacts

Public ContactShubham prajapati

MGM Dental college and hospital

drushaasnani@gmail.com9545434268

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026