Testing the effect of drug ketamine (anaesthetic agent) in reducing pain following surgery and opioid consumption by giving through erector spinae block.

Effect of erector spinae block with bupivacaine and ketamine vs bupivacaine alone on acute post operative pain and opioid consumption in patients undergoing modified radical mastectomy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/064029

Enrollment

Registered

2024-03-12

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Erector Spinae Plane Block: 1mg/kg ketamine and 30 ml of 0.25% bupivacaine will be given through the block once. Control Intervention1: Erector Spinae Plane Block: 30 ml of 0.25% bupiva

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients undergoing Modified Radical Mastectomy 2. ASA 1-3 3. 18 – 70 years of age

Exclusion criteria

Exclusion criteria: 1. Inability to communicate 2. Contraindications of Nerve Block 3. Chronic opioid or analgesic use 4. Allergic to study medications 5. BMI more than 35 6. Patients with CAD 7. Patients with preexisting dementia, h/o seizure disorder

Design outcomes

Primary

Measure	Time frame
To assess postoperative pain by NRS score Timepoint: At 1hour, 2hours, 4hours, 8hours, 12hours, 24hours	—

Secondary

Measure	Time frame
Time of activation of PCA pump Cumulative consumption of fentanyl administered through PCA Pump Acute postoperative neuropathic pain as assessed by DN4 Questionnaire Use of rescue analgesics Incidence of opioid induced adverse effects Post operative nausea & vomiting Pruritis Respiratory depression Length of hospital stayTimepoint: At 24hours, 48hours, 72hours	—

Countries

India

Contacts

Public ContactAkhil Kant Singh

All India Institute of Medical Sciences

dr.akhilsingh@gmail.com9811702808

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026