Health Condition 1: I052- Rheumatic mitral stenosis with insufficiency
Conditions
Interventions
Control Intervention1: nil: nil
Sponsors
GOVIND BALLABH PANT INSTITUTE OF POST GRADUATE MEDICAL EDUCATION AND RESEARCH NEW DELHI
Eligibility
Inclusion criteria
Inclusion criteria: rheumatic mitral valve disease of moderate seviarity includes moderate mitral stenosis/ moderate mitral regurgitation/ combination of both with any of the high risk features in form of 48-hour holter monitoring showing paroxysmal /non sustained atrial arrythmia. Trans thoracic echocardiography LA anteroposterior diameter more than 3.5cm. Abnormal LA strain or LAA velocity. LA or LAA smoke. History of transient ischemic attack in past.
Exclusion criteria
Exclusion criteria: Rheumatic mitral disease requiring intervention/surgery Associated congenital heart disease. Left ventricular systolic dysfunction Associated chronic kidney disease or known coronary artery disease. Pregnancy and lactation. Low quality echocardiographic image. Concomitant aortic stenosis and/or regurgitation .
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To measure the decrease in P wave dispersion by SGLT-2 inhibitors in rheumatic mitral valve disease.Timepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in atrial electro-mechanical coupling intervalTimepoint: 6 months;Change in LA strainTimepoint: 6 months;Change in LAA velocityTimepoint: 6 months;Change in other P wave indices PTFV1Timepoint: 6 months | — |
Countries
India
Contacts
Public ContactAbhishek nagar
Govind Ballabh Pant Institute of Post Graduate Medical Education and Research new Delhi
Outcome results
None listed