Examining the Impact of Intra-cuff Dexamethasone, Lignocaine, and their Combination on Extubation Quality and Post-operative Airway Complications in patient undergoing general anesthesia.

To assess and compare the effect of intracuff Dexamethasone, Lignocaine and combination of Dexamethasone and Lignocaine on extubation quality and post-operative airway complications (cough,sore throat and hoarseness) in patients undergoing surgery under General Aneasthesia with cuffed high volume low pressure poly-vinyl chloride(PVC) endotracheal tube-A triple blind randomised controlled study. - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/03/063980

Enrollment

Registered

2024-03-12

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intracuff drug comparison: To assess and compare the effect of intracuff Dexamethasone, Lignocaine and combination of Dexamethasone and Lignocaine on extubation quality and post-operati

Eligibility

Inclusion criteria

Inclusion criteria: BMI 18.5-29.9 Undergoing surgeries requiring general anesthesia with cuffed ETT of duration 60-120 minutes.

Exclusion criteria

Exclusion criteria: 1.Patient’s refusal participation in study. 2.Haemodynamically unstable patients. 3.History of hypertension, asthma, COPD, cardiovascular disease, renal disease, diabetes mellitus, cerebrovascular disease. 4.Patients having known hypersensitivity to drugs under consideration. 5.Patient with difficult airway with Cormack Lehane score 3 and 4, three or more attempts at laryngoscopy or bougie for intubation. 6.Patients who sustained trauma while intubation or nasogastric tube insertion as evidenced by blood on cuff after extubation or blood stained secretions while suctioning before extubation. 7.Patient suffering from active or recent (past 6 weeks) upper airway tract infection (preoperative sore throat, cough) and edema/inflammation noticed during laryngoscopy. 8.Surgery requiring placement of nasogastric tube intraopeartively. 9.Patients already on analgesics or steroids (systemic or inhaled).

Design outcomes

Primary

Measure	Time frame
a. Extubation Quality using 5 point extubation quality score. b. Post extubation airway related adverse effects like cough, sore throat and hoarseness.Timepoint: 2 hours 6 hours 12 hours 24 hours 48 hours	—

Secondary

Measure	Time frame
1. To access the haemodynamic parameter during surgery & extubation. 2. To access the airway dynamics during surgery & extubation. 3. To study side effect of study drugs if any. 4. Patient satisfaction score.Timepoint: Cuff pressure monitoring every 15 minutes during surgery Vital & peak pressure monitoring every 5 minutes Vital monitoring during Extubation every 3 minutes till 15 minutes post extubation Post operative complications and vital monitoring at 2 hour 6 hour 12 hour 24 hour 48 hour Patient satisfaction score after 48 hours	—

Measure

Time frame

1. To access the haemodynamic parameter during surgery & extubation. 2. To access the airway dynamics during surgery & extubation. 3. To study side effect of study drugs if any. 4. Patient satisfaction score.Timepoint: Cuff pressure monitoring every 15 minutes during surgery Vital & peak pressure monitoring every 5 minutes Vital monitoring during Extubation every 3 minutes till 15 minutes post extubation Post operative complications and vital monitoring at 2 hour 6 hour 12 hour 24 hour 48 hour Patient satisfaction score after 48 hours

—

Countries

India

Contacts

Public ContactElika sharma

DR RPGMC tanda kangra

bhanurpgmc@gmail.com9418016807

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026